smile1029 发表于 7 小时前

egfr19缺失,吃阿美替尼13个月肺部原发变大

详细治疗过程:

2023.7.29确诊右肺上ca,有脑转移,报告见下图
https://oss.yuaigongwu.com/pic/20241106/1730825523442460_101.png
https://oss.yuaigongwu.com/pic/20241106/1730825590714324_946.png
2023.7.31-8.5号,气管镜取病理,确诊肺腺ca,病理报告见下图
https://oss.yuaigongwu.com/pic/20241106/1730826156731409_422.jpg
然后做了次petct,提示除了脑转移,还有左侧股骨溶骨性破坏,报告见下图

(petct上提示说有肝肾转移,但后期做增强ct显示肝部是囊肿,肾是结石和囊肿,这里待下次再做次petct确定)
https://oss.yuaigongwu.com/pic/20241106/1730827070767742_637.jpg
https://oss.yuaigongwu.com/pic/20241106/1730827070770905_169.jpg
https://oss.yuaigongwu.com/pic/20241106/1730827070771943_764.png
https://oss.yuaigongwu.com/pic/20241106/1730827070772886_905.png
https://oss.yuaigongwu.com/pic/20241106/1730827070773563_35.png
https://oss.yuaigongwu.com/pic/20241106/1730827070774634_237.png
https://oss.yuaigongwu.com/pic/20241106/1730827070775778_577.png
https://oss.yuaigongwu.com/pic/20241106/1730827070775511_378.png
https://oss.yuaigongwu.com/pic/20241106/1730827070776443_265.png
https://oss.yuaigongwu.com/pic/20241106/1730827070777204_22.png
https://oss.yuaigongwu.com/pic/20241106/1730827070777759_637.png
https://oss.yuaigongwu.com/pic/20241106/1730827070778555_385.png
https://oss.yuaigongwu.com/pic/20241106/173082707077971_188.png
https://oss.yuaigongwu.com/pic/20241106/1730827070779686_777.png
https://oss.yuaigongwu.com/pic/20241106/1730827070780631_550.png
https://oss.yuaigongwu.com/pic/20241106/1730827070780708_317.png
https://oss.yuaigongwu.com/pic/20241106/1730827070781757_981.png
https://oss.yuaigongwu.com/pic/20241106/1730827070781875_367.png
等基因检测结果期间,医生给安排做了一期化疗,用药培美曲塞+顺铂+贝伐珠单抗+帕米磷酸

(这里到现在一直纠结是否有必要做这次化疗,但做了化疗以后身体素质不如之前,没化疗之前除了咳嗽闷,体感很好,还正常干着建筑类型的活,走路也很有劲)
2023.8.14号基因检测出结果,报告见下图,医生让吃阿美替尼(后来了解到奥西替尼效果会更好)后来单吃阿美替尼,没有做过放化疗,也没打贝伐珠单抗
https://oss.yuaigongwu.com/pic/20241106/1730827261979739_220.jpg
https://oss.yuaigongwu.com/pic/20241106/1730827261985772_122.jpg
https://oss.yuaigongwu.com/pic/20241106/1730827261985112_856.jpg
https://oss.yuaigongwu.com/pic/20241106/1730827261986627_634.jpg
https://oss.yuaigongwu.com/pic/20241106/1730827261987592_876.jpg
2023.9.16,吃阿美替尼一个月后复查,肌酸激酶数值升高,肝肾功有点高,但在可控的范围之内,往后复查都是肌酸激酶和肝肾功,肌红蛋白,肌酸激酶同工酶高,各项数值自己统计到表里,见下图
https://oss.yuaigongwu.com/pic/20241106/1730827869684703_893.png
https://oss.yuaigongwu.com/pic/20241106/1730827869689144_294.png
https://oss.yuaigongwu.com/pic/20241106/1730827869694765_585.png
问题:

2024.6月份复查肺部还是1.5*1.1厘米,到了9月26号复查,肺部变成2.8*2厘米,然后9月30号开始吃3粒阿美替尼,10月11号复查,肺部变成3.4*2.4,医生说吃的时间太短,让继续吃3粒阿美,到11月4号复查,肺部变成5.4*4.1厘米,长太快了

其他部位稳定,肺部长太快了,期间做过血液的基因检测,找的泛生子,没有停靶向药,不知道哪里原因,检测结果无用,吃3粒阿美以后体感上觉得不太好,稍微干点活就浑身没有劲,走路多了腿也疼,11月2号自行决定恢复吃2粒,体感恢复之前一些

现在想咨询下几个问题:

1.取病理,气管镜和穿刺,如果肿瘤位置靠近血管,哪个出血风险更大

2.基因检测机构怎么选,哪家机构准确度高

3.取病理以后是化疗好还是放疗好,因为现在只是肺部原发,如果化疗会不会对身体伤害太大,如果只对肺部放疗能否可行,利弊是什么

4.如果取完病理以后化疗更好,那是否必须联铂,单培美或者单贝伐或者单培美+贝伐效果怎么样,如果根据效果或者受益情况来排序的话,是怎么个顺序

(现在体感很好,跟正常人一样,只是偶尔有点咳嗽,不知道自己病情,一直觉得自己好好的,担心化疗后会再次跟去年时候一直,呕吐,吃不下饭,浑身没劲,特别虚弱)

问题有点多,有点太细节,麻烦论坛各位老师能给详细分析分析,谢谢

@不怕辣椒 @会飞的小企鹅 @闯关3AN2 @柳叶刀 @瓶子 @keenman @阳光~ @生命不息999 @青菜567 @HeiQiuCat @魷魚魚魚魚 @蜗牛。 @听雨12388 @申医生

下图是24年6月19肺部增强,见下图
https://oss.yuaigongwu.com/pic/20241106/1730830284490670_965.jpg
https://oss.yuaigongwu.com/pic/20241106/1730830284493831_907.jpg
https://oss.yuaigongwu.com/pic/20241106/1730830284494902_692.jpg
https://oss.yuaigongwu.com/pic/20241106/1730830284494453_311.jpg
24年9月26肺部增强,见下图
https://oss.yuaigongwu.com/pic/20241106/1730830454004866_992.jpg
https://oss.yuaigongwu.com/pic/20241106/1730830454005685_131.jpg
https://oss.yuaigongwu.com/pic/20241106/1730830454006151_990.jpg
https://oss.yuaigongwu.com/pic/20241106/1730830454007203_755.jpg
24年10月11胸部平扫,见下图
https://oss.yuaigongwu.com/pic/20241106/1730830523148166_438.jpg
https://oss.yuaigongwu.com/pic/20241106/1730830523242749_219.jpg
https://oss.yuaigongwu.com/pic/20241106/1730830523330654_148.jpg
https://oss.yuaigongwu.com/pic/20241106/1730830523415709_829.jpg
https://oss.yuaigongwu.com/pic/20241106/1730830523520148_954.jpg
24年11月4号,见下图
https://oss.yuaigongwu.com/pic/20241106/1730830553126635_858.jpg
https://oss.yuaigongwu.com/pic/20241106/1730830553198539_843.jpg
https://oss.yuaigongwu.com/pic/20241106/1730830553280508_759.jpg
https://oss.yuaigongwu.com/pic/20241106/1730830553370774_907.jpg
https://oss.yuaigongwu.com/pic/20241106/1730830553465989_573.jpg
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