看见一个 Expert Review of Anticancer Therapy。你们前面用依维莫斯，血、肝肾功能还好。下一步是否考虑索拉非尼+依维莫斯。供你参考。0 }1 i3 T1 P$ o0 y5 i
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1 z# U3 X% R2 a& j- z4 u, ]1 d/ T$ JCurrently available feasibility data for possible combination strategies. 6 A8 _' H" d3 h' T! l( L% p+ X
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Combination Feasibility according to preliminary data f2 k6 C6 h. ~( s1 E) o; S
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Bevacizumab + sorafenib Yes, reduced dose 8 P' ~! d5 H) ^" Q0 X" }
Bevacizumab + sunitinib† No
$ m1 ?* t- { q+ h# k1 M8 a0 oBevacizumab + temsirolimus Yes $ U8 ?; l6 H/ T
Bevacizumab + everolimus Yes
" _8 X! Y: i5 d/ l0 FSorafenib + sunitinib ?
" Q# s+ e3 V% x1 T! Z- aSorafenib + temsirolimus Yes, reduced dose / M' Y: b- F: L; c/ f8 T, M; H
Sorafenib + everolimus Yes, reduced dose
$ y/ z) ^* k7 jSunitinib + temsirolimus† No
% d& g) h' \- _; d) B% x$ hSunitinib + everolimus ?
$ N5 D; \2 M' w* t0 D0 F0 V2 GTemsirolimus + everolimus ? 5 A; v5 S, M4 g @# E( ]
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†Led to US FDA warning.
, G7 @# P/ ~7 W @4 w/ T% [0 `?: As yet unattempted combination.5 `: J2 p0 A- t, N5 w" G
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