发给老马备查:4 u+ A, h& @. u
滴水察海(69304838) 15:23:23
, k6 E- A3 }; |# f& a% F老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱9 N0 Z. @. t9 q2 _ V. W$ p5 ~) }
吉非替尼和S-1连用的依据
7 m' H' x _8 {! |Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro., T/ T0 k7 w. k% D- {( d
是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
7 L, M; l) E* b& g L! Q这样是不是推理出,耐药后,可以用S-1和培美了?
9 u& f- M& n7 C3 J! Q结论:
# v" p1 ?( z u( `) f; p \, X& L如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |